Ontogeny Grows the Family Tree
Executive Summary
The merger of Creative BioMolecules, Ontogeny, and Reprogenesis to form Curis Inc. was designed to build value long-term. Driven by their common focus on regenerative medicine, Curis combines near-term and longer-term product opportunities and creates a more formidable discovery engine to compete with larger companies in the field.
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In Vascular Disease, a Sustainable Model for Cell Therapy
If there's one word that ought to sum up the goal of cell therapy today, it's sustainability. Certainly that's the hope of using living cells to restore health and function to diseased tissues so that they perform as the body intended them to. But more to the point, in today's tough financing environment for venture-capital-backed start-ups, sustainability is the watchword for companies facing 15- to 20-year development curves. Tissue-engineered three-dimensional organs are complex, decades-long projects. Embryonic stem cells are much simpler in concept but are far from a commercial reality. Between those two extremes of tissue-engineering, however, there exist some well-defined opportunities, notably in the treatment of blood vessel disease. Start-ups Pervasis and Cytograft are gaining clinical validation in those areas.
Curis Reformed: Unearthing Preclinical Value
From its start as a promising powerhouse in the emerging area of regenerative medicine and through product failures, valuation crunches and capital constraints, Curis has in the past two years embraced an almost old-school approach to the biotechnology business. Bereft now of the late-stage assets (and corresponding cash burn) that helped drive its formation through merger in 2000, the company has leveraged its preclinical expertise in cell signaling to sign broad, value-creating alliances with top-shelf biotechnology and pharmaceutical partners.
Curis Reformed: Unearthing Preclinical Value
From its start as a promising powerhouse in the emerging area of regenerative medicine and through product failures, valuation crunches and capital constraints, Curis has in the past two years embraced an almost old-school approach to the biotechnology business. Bereft now of the late-stage assets (and corresponding cash burn) that helped drive its formation through merger in 2000, the company has leveraged its preclinical expertise in cell signaling to sign broad, value-creating alliances with top-shelf biotechnology and pharmaceutical partners.