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Vertex Sells Productivity

Executive Summary

Intent on finding drug leads, Vertex constructed an integrated drug-discovery platform based on understanding the structures of biological targets and then using that understanding to construct complementary compounds and compound libraries more likely to produce lead drug candidates, not simply screening hits. Its extraordinary productivity has led it to adopt a risk-reducing, alliance model, quite unlike the bet-the-farm strategies of most of its peers. Instead of focusing on a few partnerships and a few drugs for its own commercialization, Vertex has spent its time maximizing the number of programs it can put into drug development, largely through partners. To make up for the value it sacrifices by foregoing full commercialization, as well as the risks that its partners might slow development of Vertex programs, it generally insists on full control of the discovery end of R&D as well as a higher-than-average proportion of the products' end sales. Multinationals have generally balked at such deals and so the majority of Vertex's partners have been mid-sized regional players willing to cede discovery responsibilities and a larger share of the profits. But Vertex's $800 million chemogenomics deal with Novartis changes the company's deal and strategic profile; Vertex has complete authority over discovery through phase II; Novartis has control over the later stage. The deal, and its size, effectively validates and defines the Vertex strategy. Still, Vertex's focus on the early side of R&D, with less apparent commitment to creating a product franchise, has hurt its valuation, particularly at a time when investors expect biotech companies to take full advantage of at least some of the products they create.

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Novartis Out, Merck In, a Win for Vertex's Aurora Kinase Program

Earlier this year, Vertex and Novartis reworked their 2000 deal covering R&D of drugs against kinases. The shift has already proved consequential. Vertex had yet to present a compound to Novartis: the original arrangement called for Vertex to conduct all R&D through early clinical proof of concept and the most advanced molecule, VX-680, was just at IND filing. With Novartis unwilling to decide on VX-680 before seeing clinical data, as part of the renegotiation Vertex was able to regain control of the compound then license it to Merck. For that compound, at least, Vertex got from Merck what it couldn't get from Novartis: significant value and an earlier handoff of an asset.

Novartis Out, Merck In, a Win for Vertex's Aurora Kinase Program

Earlier this year, Vertex and Novartis reworked their 2000 deal covering R&D of drugs against kinases. The shift has already proved consequential. Vertex had yet to present a compound to Novartis: the original arrangement called for Vertex to conduct all R&D through early clinical proof of concept and the most advanced molecule, VX-680, was just at IND filing. With Novartis unwilling to decide on VX-680 before seeing clinical data, as part of the renegotiation Vertex was able to regain control of the compound then license it to Merck. For that compound, at least, Vertex got from Merck what it couldn't get from Novartis: significant value and an earlier handoff of an asset.

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