Biomarkers: Shaking Up--and Protecting--the World's Biggest Drug Market
The ASTEROID trial for Crestor, showing that it's the first statin known to reduce arterial plaque, has shaken up the $20 billion statin business, showing how biomarkers-not clinical endpoints-can dramatically shift share in even well established markets. And while the news was largely bad for beleaguered Lipitor, the trial's reaffirmation of the importance of potency also shows why the coming generics won't significantly hurt the market leaders.
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Pfizer was vague in describing to analysts just how it would reduce costs by $4 billion per year by 2008. The FDA's announcement that it had asked Pfizer to remove the Cox-2 inhibitor Bextra from the market just days later complicates matters for the pharmaceutical giant. In any case, those hoping for a significant headcount reduction among Pfizer sales reps were surely disappointed.
The WHO’s new "living guideline" against remdesivir’s use in hospitalized patients notwithstanding, some key opinion leaders in India see a role for the antiviral, but underscore that COVID-19 is still in its infancy and all repurposed therapies for the disease still have a long way to go. They also see the US remdesivir studies as more robust.
Join us for a brief audio tour around the past week's major global biopharma industry developments, in this podcast version of Scrip's Five Must-Know Things.