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Start-Up Previews (11/2008)

Executive Summary

A preview of the emerging health care companies profiled in the current issue of Start-Up. This month's profile group, "In Immunotherapy, Finally Time for T Cells?," features profiles of Adaptimmune, Altor BioScience, and Cell Medica. Plus these Start-Ups Across Health Care: Adnavance Technologies, Amplyx Pharmaceuticals, IlluminOss Medical, and KM Medical.

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Adnavance Technologies Inc.

Even though mortality rates double each day an MRSA infection remains untreated, most hospitals have to outsource diagnostics test to off-site labs, losing precious treatment time. Adnavance Technologies hopes to change this. The company's ADNAstat amplification-free technology enalbes rapid detection of MRSA DNA on-site at any hospital.

KM Medical Ltd.

KM Medical was formed to develop a revolutionary neonatal resuscitator to meet the needs of an underserved market. KM Medical's offering is an automatic, hand-held resuscitator with transport ventilator capability designed for controlled delivery of the small volumes of air that neonates require and a display technology that verifies that delivery.

Amplyx Pharmaceuticals Inc.

Other companies' disappointments could turn out to be blessings for Amplyx Pharmaceuticals. The start-up thinks it has a solution for ADME problems that derail candidates in clinical trials or that lead to side effects and reduced efficacy in marketed drugs. Amplyx believes it can improve problematic small-molecule drugs by extending their half-life without making the compounds too big to be delivered orally.

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