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Start-Up Previews

Executive Summary

A preview of the emerging health care companies profiled in the current issue of Start-Up. This month's profile group, "Start-Ups Against Inflammation," features profiles of Asphleia Pharmaceuticals, Calistoga Pharmaceuticals, ProtAb Ltd., and Resolvyx Pharmaceuticals. Plus these Start-Ups Across Health Care: CG Therapeutics, Healionics, Mpathy Medical Devices and Pronostics.

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Healionics Corp.

Device manufacturers looking to bolster the biocompatibility of their products can now turn to Healionics, a supplier of biomaterial scaffolds designed to improve the biointegration of percutaneous or fully implanted medical devices. The company's STAR technology is a synthetic, three-dimensional matrix, similar to a thin, porous sponge. Because this biomaterial has been precisely engineered with uniform pore sizes to the approximate size of a single cell, the company says that living tissue and new blood vessels actually grow and weave into these pores.

Mpathy Medical Devices Ltd.

Mpathy Medical Devices s focused on one of the hottest medtech markets--women's health. The company's physiologically compatible and ultra-lightweight Smartmesh technology targets the female anatomy to treat urinary stress incontinence and pelvic organ prolapse. Although Smartmesh is based on the same polypropylene material that has been used as mesh by other companies for many years for hernia repair and pelvic floor reconstruction, Mpathy Medical has innovated certain characteristics that encourage new tissue growth.

Pronostics Ltd.

Pronostics is developing molecular fingerprint profiling technology that it describes as a "digital multiplex solution. Its UltraPlex platform uses microscopic aluminum microparticles, each with a unique physical barcode etched onto the surface. Applications for UltraPlex multiplexed assays include direct immunoassays, sandwich ELISAs, DNA hybridization, activity assays, receptor binding assays, and cell-based assays. The first focus for the technology is autoimmune disease, and three UltraPlex multiplexed assays, ANA, thyroid, and celiac disease, are available.

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