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Girding For New GERD Therapies

Executive Summary

Two biotech companies, Addex Pharmaceuticals and XenoPort, are in a tight race to develop successors to the generic or soon-to-be-generic blockbuster proton pump inhibitors. As the firms' drugs proceed through clinical trials, their respective outcomes are an object lesson for biotechs and pharmaceutical companies looking to enter a crowded space already well served by existing medicines.

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The discovery of metabotropic glutamate receptors in the early '90s opened up a new world of potential drug targets in CNS diseases and beyond. But targeting specific mGluRs proved difficult; eventually the challenge of designing selective molecules led to breakthroughs modulating receptors at sites distinct from the endogenous binding site. This so-called allosteric modulation may help to clear a logjam of undruggable GPCRs and other receptors. Creating drug-like molecules remains a challenge but industry, after some false starts, is poised to make advances as compounds begin to hit proof-of-concept in man.

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