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Start-Up Previews, June 2014

Executive Summary

Profiles of AdverseEvents, AventaMed, Ensysce Biosciences, Jounce Therapeutics, LensGen, Marvao Medical Devices, Pharmasum Therapeutics, and Rotation Medical.

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AventaMed Ltd.

More than 2.2 million cases of otitis media with effusion are diagnosed each year worldwide, with as many as 90% of children having at least one episode by age 10. The standard treatment is surgical placement of tiny tympanostomy tubes to ventilate the middle ear space, but AventaMed Ltd. is working to dramatically reduce costs in treating OME and to improve the patient experience with a novel device for tympanostomy tube placement that takes less than one second in an office setting.

Rotation Medical Inc.

Rotation Medical Inc.’s implantable collagen scaffold induces formation of new tendon-like tissue, and in some cases eliminates the need for suture anchors in surgical repair. This new technique has the potential to prevent rotator cuff disease progression and significantly reduce the incidence of re-tears.

Marvao Medical Devices Ltd.

Catheter-related bloodstream infections are the bane of tunneled dialysis catheters, despite the widespread use of antimicrobial dressings or an injection cap placed on the exit site of the catheter to help protect the inside of the catheter from becoming colonized. The NexSite Hemodialysis Catheter from Marvao Medical Devices Ltd. is designed to reduce these bloodstream infections with a protective biomaterial tissue ingrowth scaffold that is part of the catheter and positioned at the skin exit site.

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