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Start-Up Previews, June 2015

Executive Summary

This Month's Profile Group, Skin Is In With Biomedical Investors, features profiles of Aclaris Therapeutics, Alexar Therapeutics, Rogne Bioscience, and Scioderm. Plus these Start-Ups Across Health Care: Harpoon Medical, OcuSciences, Oncoceutics, Pelvalon, and Procyrion.

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Harpoon Medical Inc.

Harpoon Medical's Inc.'s beating heart mitral valve procedure uses an expanded polytetrafluorethylene anchor that replaces the non-functioning natural chordae tendineae. The anchor is inserted via a small incision between the ribs and into the leaflet to eliminate mitral valve regurgitation.

OcuSciences Inc.

OcuSciences Inc.'s OcuMet Beacon is a noninvasive and rapid diagnostic screening tool for retinal disease. The current ophthalmic standard of care, optical coherence tomography, evaluates structural change in retinal thickness or swelling after retinal damage has occurred, but OcuMet can provide a level of functional testing before damage occurs, which is especially important for latent diabetics or patients undiagnosed for retinal diseases.

Pelvalon Inc.

Pelvalon Inc.'s Eclipse System, a non-surgical vaginal insert for fecal incontinence in women, is composed of an inflatable balloon attached to a base. When inflated via a handheld pump connected to the device, the balloon exerts pressure on the vaginal wall, thus compressing the rectum to prevent stool from passing.

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