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Start-Ups in Brief (4/03)

Executive Summary

In Vivo Europe Rx briefly summarizes the technologies of four recent European start-ups: Belgium's 4 AZA Bioscience NV, Germany's responsif GMBH, the UK's Sphere Medical Ltd., and Switzerland's Xigen SA.

4 AZA Bioscience NV

Kapucijnenvoer 33

3000 Leuven

Belgium

Phone: +32 16 29 29 23

Fax: +32 16 29 06 92

E-Mail: [email protected]

Web Site: www.4aza.com

Management: Benoît Verjans, CEO; Valery Libert, PhD, CSO; Mark Waer, PhD, Piet Herdewijn, PhD, Wolfgang Pfleiderer, PhD, Scientific Founders

Company Founded: April 2002

Financing to Date: $ 4.7 million (€4.5 million)

Investors: Capricorn Venture Fund II; Fortis Private Equity; Fagus; KBC Investco; Gemma Frisius Fund, University of Leuven.

Employees: Undisclosed

Partners/Alliances: University of Leuven

Industry Segment: Pharmaceuticals

Business: Spun-off from the University of Leuven with a library of 1500 heterocyclic compounds and proprietary discovery tools, 4 AZA Bioscience will develop novel T-cell inhibitors for immune diseases and related compounds for neurodegenerative disease and cancer.

responsif GMBH

Ulrich-Schalk-Strasse 3

91056 Erlangen

Germany

Phone: +49 9131 75088 400

Fax: +49 9131 75088 439

E-Mail: [email protected]

Web Site: www.responsif.de

Management: Christian Reiser, PhD, Managing Director

Company Founded: December 2002

Financing to Date: Undisclosed

Investors: Undisclosed

Employees: 15

Partners/Alliances: november AG

Industry Segment: Biotechnology

Business: responsif was spun-out of november AG to commercialize therapeutic vaccines for cancer. The company's technology involves ex vivo treatment of cells from a patient's tumor, then reinjection of those cells to trigger an immune response and destroy any remaining metastasized cells.

Sphere Medical Ltd.

Harston Mill

Harston, Cambridge CB2 5GG

UK

Phone: +44 1223 875225

Fax: +44 1223 875201

E-Mail: [email protected]

Web Site: www.spheremedical.com

Management: Stuart Hendry, PhD, CEO; Gavin Troughton, PhD, VP Business

Development

Company Founded: September 2002

Financing to Date: $567,000 (€525,000); $7.5 million round in progress.

Investors: Siemens Technology Accelerator; Generics Group AG

Employees: 8

Partners/Alliances: Siemens AG

Industry Segment: Molecular and Clinical Diagnostics

Business: Sphere Medical was formed around microelectrochemical systems (MEMS) silicon sensing technology acquired from Siemens, and has also in-licensed molecular imprinting technology. The company will use its platform, which combines numerous chemical sensors on a single silicon chip along with integrated electronic drive circuitry, to build low-cost, real-time diagnostic and analytical

products.

Xigen SA

Chemin des Falaises 1

CH-1005 Lausanne

Switzerland

Phone: +41 21 314 33 96

Fax: +41 21 314 33 85

E-Mail: [email protected]

Web Site: www.xigen.ch

Management: Peter Harboe-Schmidt, CEO; Christophe Bonny, PhD, CSO

Company Founded: January 2002

Financing to Date: Undisclosed

Investors: Private

Employees: 4

Partners/Alliances: University Hospital of Lausanne

Industry Segment: Biotechnology

Business: Xigen is developing novel anti-apoptotic small peptide drugs designed to block undesired intracellular protein-protein interactions that underlie a variety of diseases and disorders including Type 1 diabetes, Alzheimer's disease and hearing loss.

Send information on your start-up to [email protected]

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