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QSI Pharma AS

Executive Summary

QSI Pharma, a Danish start up formed by the Technical University of Denmark and the biotech incubator of Leo Pharma AS, aims to inhibit the formation of deadly biofilms, highly structured and virulent communities of surface colonizing bacteria. QSI aims to discover molecules that interfere with bacterial quorum sensing, a cell-cell signaling process by which bacteria form biofilms when sufficient bacteria have amassed. The company's first target is Pseudomonas aeruginosa, which is responsible for a significant percentage of deaths from many hospital-acquired infections.

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Athelas Ltd.

Geneva-based start up Athelas Ltd. aims to develop anti-infective drugs based on new bacterial targets it discovers through its DiVi platform. The company's platform is based on the use of the amoeba as a model organism--by engineering single-gene mutant bacteria and infecting the amoebas with those bacteria, Athelas' scientists aim to identify drug targets that may be important in vivo, but that might not be found via traditional in vitro screening methods.

Athelas Ltd.

Geneva-based start up Athelas Ltd. aims to develop anti-infective drugs based on new bacterial targets it discovers through its DiVi platform. The company's platform is based on the use of the amoeba as a model organism--by engineering single-gene mutant bacteria and infecting the amoebas with those bacteria, Athelas' scientists aim to identify drug targets that may be important in vivo, but that might not be found via traditional in vitro screening methods.

Arrow: Focus and Flexibility

In October 2003, infectious diseases start-up Arrow Therapeutics' £21 million funding round from four new international VCs and five existing backers topped the ranks of UK biotech fundraisings. The round shows that investors value a broad pipeline, plus well-connected management able to balance focus with opportunism, more than a product in the clinic or a sexy new technology.

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