Could A Type 1 Diabetes Immunotherapy Be In Reach?
Executive Summary
Promising data from the likes of Provention Bio and Diamyd Medical suggest that treatment for the autoimmune disorder type 1 diabetes could soon move beyond insulin.
You may also be interested in...
EMA Accepts First Diabetes Drug Onto PRIME
Provention Bio’s teplizumab, a potentially game-changing treatment for preventing or delaying type 1 diabetes, is one of three investigational products to be newly accepted onto the European Medicines Agency’s popular priority medicines scheme.
GSK & Tolerx suffer Phase III otelixizumab setback
Targeting CD3 to treat type 1 diabetes has once again been called into question as GSK and Tolerx revealed that the Phase III DEFEND-1 study of otelixzimuab did not meet its primary endpoint in patients with new-onset autoimmune type 1 diabetes. The partners have suspended new recruitment and dosing in the DEFEND-2 study pending review of the DEFEND-1 results. Last autumn, MacroGenics and partner Eli Lilly announced that their anti-CD3 mAb failed to show efficacy in a pivotal Phase II/III trial in type 1 diabetes patients missing the same primary endpoint.
Sanofi Prepares Pulmonologists As Dupixent Nears COPD Finishing Line
The French drugmaker has identified education as a key challenge ahead of its June action date for the huge-selling IL4/IL-13 inhibitor in the lung condition. An approval would make it the first biologic for the disease.