Animal testing
This article was originally published in The Rose Sheet
Executive Summary
Murine local lymph node assay accepted by FDA, the Environmental Protection Agency, Consumer Product Safety Commission and Occupational Safety & Health Administration as an alternative test method for contact dermatitis, the National Institutes of Health announces Dec. 28. The mouse trials can be conducted using fewer animals in most situations, NIH says. The LLNA test also results in less stress on the mice and can be conducted within a week, compared to three to four weeks for the guinea pig test. LLNA was accepted as a viable alternative to guinea pig tests by the Inter-Agency Coordinating Committee for the Validation of Alternative Methods in early 1999 and sent to the federal agencies for review (1"The Rose Sheet" March 29, 1999, p. 9). The assay is the first to clear the validation process
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Animal testing
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Animal testing
Corrositex synthetic skin test accepted as an in vitro replacement to traditional animal tests for dermal corrosivity by the Environmental Protection Agency, Occupational Safety & Health Administration and Consumer Product Safety Commission, the National Institute's of Health's National Toxicology Program announces. The approval will be formally announced in upcoming Federal Register notices. InVitro International's Corrositex is an alternative to an existing in vivo method that involves testing several thousand laboratory rabbits each year. The Inter-Agency Coordinating Committee for the Validation of Alternative Methods unanimously recommended Corrositex in June 1999 (1"The Rose Sheet" June 28, 1999, p. 12). Corrositex is the second ICCVAM-recommended test to receive governmental approval; murine LLNA was accepted in January (2"The Rose Sheet" Jan. 10, In Brief)
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