In Vivo is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By


Animal testing

This article was originally published in The Rose Sheet

Executive Summary

Murine local lymph node assay accepted by FDA, the Environmental Protection Agency, Consumer Product Safety Commission and Occupational Safety & Health Administration as an alternative test method for contact dermatitis, the National Institutes of Health announces Dec. 28. The mouse trials can be conducted using fewer animals in most situations, NIH says. The LLNA test also results in less stress on the mice and can be conducted within a week, compared to three to four weeks for the guinea pig test. LLNA was accepted as a viable alternative to guinea pig tests by the Inter-Agency Coordinating Committee for the Validation of Alternative Methods in early 1999 and sent to the federal agencies for review (1"The Rose Sheet" March 29, 1999, p. 9). The assay is the first to clear the validation process

Related Content




Ask The Analyst

Ask the Analyst is free for subscribers.  Submit your question and one of our analysts will be in touch.

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts