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SACATM meeting

This article was originally published in The Rose Sheet

Executive Summary

The Peer Review Report, "The Use of In Vitro Basal Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Testing," will be reviewed and discussed during the Scientific Advisory Committee on Alternative Toxicological Methods teleconference taking place Aug. 3 from 1 p.m. to 4 p.m., committee announces. Panel Report includes section that addresses the "rationale for the use of in vitro neutral red uptake cytotoxicity test methods to predict starting doses for in vivo acute oral systemic toxicity testing" and a section on the accuracy of the 3T3 and NHK NRU test methods. During a May 23 meeting of the Interagency Coordinating Committee on the Validation of Alternative Methods, a scientific peer review panel concluded the 3T3 and NHK methods are sufficient for use in a weight-of-evidence approach to determine the starting dose for acute oral in vivo toxicity testing (1"The Rose Sheet" May 29, 2006, p. 8)...
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