In Vivo is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By


2011 Scrip 100: CNS trials

This article was originally published in Scrip

Executive Summary

In the CNS therapeutic area, 303 industry-sponsored Phase II and Phase III trials were initiated between 1 October 2009 and 30 September 2010. Phase II and Phase III trial starts were equally split, with continuing high interest in pain. Nociceptive pain had more new Phase II starts (27) and total initiated trials (54) than any other indication. Neuropathic pain ranked next in terms of trial starts (32) and nearly half of these targeted pain caused by diabetic neuropathy. Combining trials for both nociceptive and neuropathic pain symptoms, pain relief represented nearly one-third of total trial starts, reflecting a continuing industry trend of yearly R&D expenditure in this competitive area. Depression and multiple sclerosis followed pain as areas of steady interest. In depression, 21 of 31 trials were Phase III starts, most aimed at drug registration. These included Lundbeck's LuAA21004 and AstraZeneca's TC-5214, with both companies planning to file new drug applications in 2012. Trials initiated in MS remained high despite the recent approval of the first oral medication, FTY720. Phase II schizophrenia trials targeted cognitive dysfunction, while Phase III trials aimed at new oral formulations for approved drugs. Alzheimer's disease trials were overwhelmingly Phase II (16 of 22 trials), reflecting the difficulty in demonstrating significant efficacy in large Phase III studies, as seen in the failure of both the histamine receptor antagonist Dimebon and the secretase gamma inhibitor LY450139 programmes. Parkinson's disease, with 17 of 20 trial starts in Phase III, showed robust pipeline advancement in this area.

You may also be interested in...

Pandemic Response In US Consumer Health Market: OTC Pain Relief And Cough/Cold Purchases

Pain relief product sales grew 27% and upper respiratory sales 35% for the week ended 7 March as consumers respond to COVID-19, according to Nielsen data noted in a Jefferies report on consumer health purchasing trends. Private label market share is up slightly, while OTC purchases continue primarily in conventional stores.

venBio Raises $394m To Fund Biopharmas Through Human Proof-Of-Concept

Managing partner Corey Goodman said venBio didn’t have trouble closing its fund, because the venture capital firm prepared its investors for an economic downturn months ago.

FDA Wants To Put Hep C Tests On 510(k) Pathway

The US FDA has proposed moving two categories of hepatitis C diagnostics to class II from class III because they pose relatively low risk.


Related Companies




Ask The Analyst

Ask the Analyst is free for subscribers.  Submit your question and one of our analysts will be in touch.

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts