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Isis ends RA, continues cardiovascular programs for ISIS-CRPRx

This article was originally published in Scrip

Executive Summary

Isis Pharmaceuticals will discontinue development of ISIS-CRPRx in the treatment of rheumatoid arthritis (RA) after the antisense drug targeting C-reactive protein (CRP) decreased CRP by as much as 67%, but did not provide a statistically significant improvement in the signs and symptoms of RA compared with placebo in a 51-patient Phase II clinical trial.






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