In Vivo is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By


Phrixus Pharmaceuticals Inc.

Latest From Phrixus Pharmaceuticals Inc.

Phrixus Pharmaceuticals Inc.

Phrixus Pharmaceuticals Inc. aims to repurpose a compound that may be able to boost the blood-pumping capacity of damaged hearts. Carmeseal was originally developed in the 1950s by BASF as a surfactant called poloxamer-188. If results seen in several animal cardiovascular models can be reproduced in humans, Phrixus’ compound could become an emergency room treatment for acute decompensated heart failure.

Despite Challenges, Congestive Heart Failure Draws A Crowd

Across the industry, cardiovascular R&D budgets are shrinking, and in some cases, practically disappearing. Some large companies are de-emphasizing the cardiovascular space, citing factors ranging from the size and high expense of clinical trials to the challenge of proving benefit when most experimental therapies are tested in tandem with current standards of care. Nonetheless, for those companies still willing to venture into the cardiovascular arena, congestive heart failure (CHF) offers a huge, lucrative indication to pursue. Several start-up firms are targeting CHF and related conditions by a variety of mechanisms, including polymer therapeutics, microRNA targeting and gene therapy. In this issue, we profile four such start-ups: miRagen Therapeutics, NellOne Therapeutics, Phrixus Pharmaceuticals and Sorbent Therapeutics.
BioPharmaceutical Research and Development Strategies

Start-Up Previews (04/2010)

A preview of the emerging health care companies profiled in the current issue of Start-Up. This month's profile group, "Despite Challenges, Congestive Heart Failure Draws A Crowd," features profiles of miRagen, NellOne Therapeutics, Phrixus Pharmaceuticals and Sorbent Therapeutics. Plus these Start-Ups Across Health Care: Ambicare, Anulex Technologies, NeoTract and Sistemic.
See All

Company Information

  • Industry
  • Biotechnology
  • Pharmaceuticals
  • Therapeutic Areas
  • Cardiovascular
  • Alias(es)
  • Ownership
  • Private
  • Headquarters
  • Worldwide
    • North America
      • USA
  • Parent & Subsidiaries
  • Phrixus Pharmaceuticals Inc.
  • Senior Management
  • Contact Info
  • Phrixus Pharmaceuticals Inc.
    Phone: (734) 358-9015
    300 N. 5th Ave., Ste. 150
    Ann Arbor, MI 48104