With FDA’s blessing, Stealth BioTherapeutics is working toward a pivotal trial that would address an underlying cause, mitochondrial myopathy, of roughly 270 very rare diseases, potentially leading to an aggregate approval in all of those unmet medical needs.

Recent executive-level hires and director appointments at venture capital firms and biopharma and medtech start-ups.

Recent executive-level company changes and promotions in the biopharma, medical device, and diagnostics industries.

The year was marked by record levels of biopharma M&A activity and a strong IPO market. Measures designed to deliver early access to new medicines continued to advance on both sides of the Atlantic, while pricing came in for renewed attention as new, highly effective but extremely expensive products reached the market.