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Start-Up Previews (10/2007)

Executive Summary

A preview of the emerging health care companies profiled in the current issue of Start-Up. This month's profile group, "Cardiovascular Drug Start-Ups," features profiles of AcelleRX Therapeutics, BioVascular, Nile Therapeutics and VIA Pharmaceuticals. Plus these Start-Ups Across Health Care: JenaValve, Moberg Derma, ProtAffin, and Virtual Ports.

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AcelleRX Therapeutics Inc.

AcelleRX Therapeutics aims to help people who suffer a myocardial infarction (MI) or chronic heart failure (HF) via a gene or protein capable of recruiting stem cells to help repair the heart. If the science can be successfully commercialized, this spin-out from the Cleveland Clinic in Ohio could have a big impact on a big slice of the market.

Nile Therapeutics Inc.

For patients with acute decompensated heart failure, Nile Therapeutics is developing a drug related to known natriuretic peptides, which addresses three important mechanisms. CD-NP shows promise in fluid unloading, but without the side effect of low blood pressure that often accompanies other medications; it as the potential to reduce filling pressure; and it may also preserve, or possibly enhance, renal function.

Moberg Derma AB

Swedish dermatology specialty pharma Moberg Derma AB is using its Kaprolac platform to build a portfolio of non-steroidal, topical treatments that it thinks will have improved therapeutic outcomes and mitigated side-effect profiles. Kaprolac is a combination of several well-known, safe dermatological compounds that have given rise to a potential 10 new treatments in Moberg Derma's pipeline.

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